AgRP to Kiss1 neuron signaling links nutritional state and fertility
نویسندگان
چکیده
منابع مشابه
Starvation after AgRP neuron ablation is independent of melanocortin signaling.
Ablation of inhibitory agouti-related protein (AgRP)-expressing neurons in the arcuate nucleus that also synthesize gamma-amino-butyric acid (GABA) and neuropeptide Y in adult mice leads to starvation within 1 week. The removal of inhibition from the AgRP neurons onto neighboring proopiomelanocortin neurons and their common postsynaptic neurons is predicted to stimulate melanocortin signaling, ...
متن کاملInsulin and Leptin Signaling Interact in the Mouse Kiss1 Neuron during the Peripubertal Period
Reproduction requires adequate energy stores for parents and offspring to survive. Kiss1 neurons, which are essential for fertility, have the potential to serve as the central sensors of metabolic factors that signal to the reproductive axis the presence of stored calories. Paradoxically, obesity is often accompanied by infertility. Despite excess circulating levels of insulin and leptin, obese...
متن کاملLeptin Signaling in AgRP Neurons Modulates Puberty Onset and Adult Fertility in Mice.
The hormone leptin indirectly communicates metabolic information to brain neurons that control reproduction, using GABAergic circuitry. Agouti-related peptide (AgRP) neurons in the arcuate nucleus are GABAergic, express leptin receptors (LepR), and are known to influence reproduction. This study tested whether leptin actions on AgRP neurons are required and sufficient for puberty onset and subs...
متن کاملAgrp neuron activity is required for alcohol-induced overeating
Alcohol intake associates with overeating in humans. This overeating is a clinical concern, but its causes are puzzling, because alcohol (ethanol) is a calorie-dense nutrient, and calorie intake usually suppresses brain appetite signals. The biological factors necessary for ethanol-induced overeating remain unclear, and societal causes have been proposed. Here we show that core elements of the ...
متن کاملCorrigendum: Agrp neuron activity is required for alcohol-induced overeating
This corrects the article DOI: 10.1038/ncomms14014.
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2017
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1621065114